Therapeutic efficacy of cancer stem cell vaccine

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Therapeutic efficacy of cancer stem cell vaccine

Methods We have developed a strategy to target the CSC populations in melanoma and squamous cell carcinoma using CSC lysate-pulsed dendritic cells (DC). D5 is a poorly immunogenic clone of the melanoma cell line B16 syngeneic to B6 mice. In minimal tumor model, B6 mice were inoculated subcutaneously with D5 cells. The 1st vaccine was administered 24 hours after tumor inoculation for treatment, ...

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Cancer stem cells: therapeutic targets

Cancer stem cells (CSCs) have been identified as rare cellular populations in many cancers, including leukemia and solid tumors. This minor subpopulation of cancerous cells is immortal tumor-initiating cells which thought to be responsible for cancer initiation, progression, metastasis, recurrence and drug/radiation resistance. Low proliferative rate, high self-renewing capacity, differentiatio...

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Therapeutic angiogenesis promotes efficacy of human umbilical cord matrix stem cell transplantation in cardiac repair

Objective(s):Although previous studies have confirmed the beneficial effects of human umbilical cord matrix stem cell (hUCM) transplantation post myocardial infarction (MI), but this stem cell resource has no potential to induce angiogenesis. In order to achieve the process of angiogenesis and cardiomyocyte regeneration, two required factors for cardiac repair agents were examined namely; hUCM ...

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Promise of cancer stem cell vaccine

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ژورنال

عنوان ژورنال: Journal for ImmunoTherapy of Cancer

سال: 2015

ISSN: 2051-1426

DOI: 10.1186/2051-1426-3-s2-p29